4-甲氧基-3-卤代联苯的合成研究

Study on Synthesis of 4-methoxy-3-halogenated biphenyl

摘要:

该文以对甲氧基联苯胺为原料，在-5～0℃下进行重氮化，进一步与氯化亚铜或溴化亚铜在90℃发生Sandmeyer反应，得到4-甲氧基-3-卤代联苯，考察了原料配比、反应温度和反应时间等对反应的影响，并通过熔点、红外光谱、核磁共振等对其进行了表征。研究结果表明：采用本方法合成的3-氯-4-甲氧基联苯的总收率为63%，3-溴-4-甲氧基联苯的总收率为51%。

Abstract:

4-methoxy-3-halogenated biphenyl was synthesized from p-dimethoxybenzidine via diazotization at -5～0℃ and Sandmeyer reaction with Cuprous Bromide or Cuprous chloride at 90℃, Some factors affected the reaction，such as the mw material rate，the reaction time and the reaction temperature were also discussed. The structure of the product was confirmed by melting point, IR and 1H NMR .The results show that the total yield of 3-Chloro-4-methoxybiphenyl synthesized by this preparation procedure was 63% and 3-Bromo-4-methoxybiphenyl was 51%.