三羟甲基丙烷三水杨酸酯的合成与研究

Synthesis and Application of Trimethylolpropane trisalicylate

摘要:

合成了三羟甲基丙烷三水杨酸酯。在N2的保护下，以水杨酸和TMP（三羟甲基丙烷)为原料，采用醇酸直接酯化法合成三羟甲基丙烷三水杨酸酯。通过IR，MS，1H-NMR等手段进行表征，确证了目标产物的结构。考察了反应温度、催化剂种类、反应时间、TMP的羟基与水杨酸羧基的摩尔比对反应的影响，获得适宜的反应条件：水杨酸质量4 %的对甲苯磺酸为催化剂，N2保护下反应温度为160 ℃,反应时间为6 h，n(水杨酸的基)：n(三羟甲基丙烷（TMP）的羟基)=1:0.7,酯化率达99.5 %。并进一步研究了该酯类的抑菌性能,结果表明：该酯类对大肠杆菌具有明显抑菌性能。

Abstract:

The synthesis of trimethylolpropane trisalicylate was implemented.Under the protection of nitrogen,trimethyl-olpropane trisalicylate was synthesized by direct este-rification process when trimethylolpropane and salicyl- ic acid was used as reactants, the product was analyzed by IR、1H-NMR、MS. The structure of the target product was confirmed. The influencing factors, such as tempe- rature, catalyst, molar ratio of salicylic acid to tri-methyololpropane and reaction time were studied.The op- timum reaction conditions were obtained as follows: tosic acid as catalyst, molar ratio of the carboxyl of salicylic acid to the hydroxy of trimethyolpropane 1:0.7, reacting in N2 for 6 h at 160 ℃. Under the optimum con- ditions the yield of the product reached 99.5 %. The anti-bacterial properties of the esters were studied, the results showed that: the trimethylolpropane trisalicylate has the very obvious inhibitory effects to Escherichia coli.