2,3-苯并环庚酮的合成

Synthesis of 2, 3-Benzosuberone

摘要:

以苯和戊二酸酐为原料，经取代反应、沃夫-黄鸣龙还原和环化脱水，制得2,3-苯并环庚酮，最优反应条件为：n(戊二酸酐):n(苯):n（三氯化铝）=1:2:2，室温反应3h，溶剂为四氢呋喃；沃夫-黄鸣龙还原反应温度为160℃，反应时间为2h；环化脱水反应温度为120℃，时间2h，反应总收率60.3%，用IR、1HNMR、13CNMR及MS对中间体及目标产物结构进行了表征。

Abstract:

2,3-benzosuberone was synthesized using benzene and glutaric anhydride as raw materials through Friedel-Crafts reaction, Wolff–Huang-Minlon reduction and cyclodehydration. Under the optimum reaction conditions of n(glutaric anhydride) :n(benzene):n(AlCl3)=1:2:2, at room temperature for 3h, and reduction at 120℃ for 2h, then cyclodehydration at 160℃ for 2h, the overall yield was 60.3%. Structures of the intermediates and the final product were characterized by IR, NMR and MS.