2-巯基-5-甲氧基咪唑并[4,5-b]吡啶的合成

Synthesis of 2-Mercapto-5-methoxyimidazo[4,5-b]pyridine

摘要:

该文以2,6-二氯吡啶为原料，用甲醇/氢氧化钠体系进行甲氧基取代，用硝酸钾/浓硫酸进行硝化反应，再用氨水氨解，制得2-氨基-3-硝基-6-甲氧基吡啶（III），最后用氯化亚锡在75℃下反应4h还原III，再用二硫化碳环化合成2-巯基-5-甲氧基咪唑并[4,5-b]吡啶，总收率为43.6%。产物结构用IR、1HNMR和MS作了表征。

Abstract:

A Synthesis route of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine was discussed. The router was : 2,6-dichloropyridine as the starting material was reacted with methanol/sodium hydroxide, after treated by potassium nitrated/concentrated sulfuric acid, then ammoniation to give 2-amino-6-methoxy-3-nitropyridine(III) which was finally reduced by tin chloride under 75℃ for 4h and cyclized by carbon disulfide to give the target compound .The overall yield reached 43.6%. The structure of product was characterized by IR, 1H-NMR and MS spectra.