大孔磺酸树脂催化合成7-羟基-4-甲基香豆素

Synthesis of 7-hydroxy-4-methyl coumarin catalyzed by macroporous sulfoacid resin

摘要:

7-羟基-4-甲基香豆素是重要的化工中间体。研究了DT-852大孔磺酸树脂催化合成7-羟基-4-甲基香豆素的工艺。结果表明，DT-852大孔磺酸树脂具有较好的催化活性；7-羟基-4-甲基香豆素较佳的合成工艺为：反应温度105 oC，反应时间2.5 h，催化剂用量1.0 g，物料比n (乙酰乙酸乙酯):n (间苯二酚)=1:1，产率为93.8%，w (7-羟基-4-甲基香豆素)＝98.27%(HPLC)，催化剂可重复使用多次。产品用mp和IR验证。

Abstract:

7-hydroxy-4-methyl coumarin is an important chemical intermediate. DT-852 macroporous sulfonic acid resin is developed as efficient catalyst in synthesis of 7-hydroxy-4-methyl coumarin technology. Results show: DT-852 macroporous sulfonic acid resin has well catalytic activity; The better synthesis conditions for 7-hydroxy-4-methyl coumarin were: reaction temperature 105 oC and reaction time 2.5 h, 1.0 g catalyst, material ratio ethyl acetoacetate to resorcinol 1.0, the yield was 93.8%, w (7-hydroxy-4-methyl coumarin) = 98.27% (HPLC). Catalyst can be reused many times. Product was verified with mp and IR.