质子泵抑制剂的合成研究

Research on Synthesis of Proton Pump Inhibitors

摘要:

胃酸被认为是消化性溃疡的最主要致病因素之一，无论手术治疗还是药物治疗，减少胃酸分泌都是促进溃疡愈合的最常用手段。质子泵抑制剂是一类新型的抑制胃酸分泌的药物。叙述了质子泵抑制剂及关键中间体2-巯基苯并咪唑化合物，2-巯基咪唑并[4,5-b]吡啶化合物，2-氯甲基吡啶化合物的合成研究概况，探讨了质子泵抑制剂的较佳合成方案和结构设计思路。

Abstract:

Clinically duodenal and peptic ulceration are the most common diseases. Control of the gastric pH with antisecretory drugs has proven to be an effective method in the treatment of duodenal and peptic ulcers. Proton pump inhibitors have been proved to be the most effective drugs in curing ulcers. The research advance of various synthetic methods of proton pump inhibitors were reviewed. The research advance for the synthesis of key intermediates 2-mercapto-benzimidazoles,2-mercapto-imidazo[4,5-b]pyridines and 2-chloromethyl pyridine compounds were summarized. The optimum synthetic scheme was discussed.