环(N-甲基亮氨酰-亮氨酰- N-甲基亮氨酰-亮氨酰-亮氨酰)的合成

Synthesis of cyclo(Leu-N-MeLeu-Leu-Leu- N-MeLeu)

摘要:

以亮氨酸为起始原料，改变环合位点，对具有抗肿瘤活性的环五肽化合物环（亮氨酰-N-甲基亮氨酰-亮氨酰-N-甲基亮氨酰-亮氨酰）进行全合成，该路线反应条件温和，环合收率为53.7%。通过1HNMR,13CNMR,MS对其结构进行了表征。

Abstract:

Cyclo(Leu-N-MeLeu-Leu-N-MeLeu-Leu), with antiproliferative activities, has been synthesized with leucine for the starting material. The efficiency of cyclization is 53.7%. The structures of product and intermediates were characterized by 1HNMR, 13CNMR and MS. All reactions were mild.