羟基酪醇合成工艺研究

The New Process Research of Hydroxytyrosol Synthesis

摘要:

以邻苯二酚为起始原料，经过保护邻二酚羟基，溴化制得3,4-亚甲二氧基溴苯，制备其格氏试剂，再用格氏试剂与环氧乙烷反应，最后脱掉保护基团，以五步反应24%的总收率得到高纯度羟基酪醇，并通过IR, MS等方法对终产物进行了表征。

Abstract:

The new process of hydroxytyrosol synthesis had been discovered, which starts from catechol protection, followed by 3-bromation to give 1-Bromo-3,4-(methylenedioxy)benzene, then preparation of Grignard reagent and reaction with ethylene oxide and, finally, deprotection. Hydroxytyrosol was obtained by five-step reaction with high purity in the overall yield of 24%. The title compound was characterized with IR and MS.