L-瓜氨酸与L-高瓜氨酸的绿色合成工艺

Green synthesis of L-citrulline and L-homocitrulline

摘要:

以L-鸟氨酸盐酸盐为原料与五水硫酸铜反应生成二鸟氨酸合铜保护α-NH2保护、用尿素对δ-NH2甲酰化得到二瓜氨酸合铜，后用二水合草酸脱α-NH2保护得到目标产物L-瓜氨酸，总收率49.5%。用同样的方法以L-赖氨酸盐酸盐为原料制备了L-高瓜氨酸，总收率53.5 %。产物经IR、熔点、旋光确证。该方法具有操作方便、安全、经济和环保等特点。

Abstract:

An novel method for synthesis of L-citrulline and L-homocitrulline was reported. In this process, L-ornithine monohydrochloride was reacted with copper Sulfate pentahydrate to protect α-NH2, and δ-NH2 was carbamylated with carbamide, then copper ion was removed through combination with oxalate dihydrate to give L-citrulline with an overall yield of 49.5 %. L-homocitrulline was prepared from L-lysine monohydrochloride in the same method with an overall yield of 53.5%. The structure of aimed compound was confirmed by IR, melting point and optical rotation. This synthetic route was convenient, safe, economical, and environmental friendly.