甘油合成1,3-丙二醇

Synthesize of 1, 3-propanediol from glycerol

摘要:

以甘油为原料，经过氯代、氧化、克莱门森还原、水解等四步反应最终合成1,3-丙二醇。并用红外色谱仪和质谱仪对目标产物进行结构确定。从反应物摩尔比、反应温度、反应溶剂等优化了反应条件。最优反应条件为：氯代反应为：温度120℃；氧化反应为：温度23～27℃，n(1,3-二氯2-丙醇):n(重铬酸钠)=1.8:1，反应溶剂用量m(1,3-二氯2-丙醇)：v(水) =1.4 g：1 ml；克莱门森还原为：n(1,3-二氯丙酮):n（锌）=1:1.2，水作反应溶剂最佳；1,3丙二醇总产率可达37.1%。

Abstract:

1, 3-propanediol was synthesized from glycerol by chloration, oxidation, Clemmensen reaction and hydrolysis. The structure of the target compound was determined with IR and MS. The molar ratio, temperature and solvent of the reaction were investigated to optimize the reaction conditions. The optimum conditions: for chloration: 120 ℃; for oxidation: 23-27 ℃, n (1,3-Dichloroacetone) : n (sodium dichromate) = 1.8:1, v(water): m (1,3-Dichloroacetone equaling) = 1 ml:1.4 g; and for Clemmensen reaction: n (1,3-Dichloropropane) : n (zinc) = 1:1.2 with water as the solvent, the overall yield was 37.1%.