三齿仲胺配合物的合成、表征及生物活性的研究

Synthesis、Characterization and Biological Activities Investigation of tridentate secondary amine complexes

摘要:

合成了一种新型三齿配体N-(4-甲基苯)-N′-(2-(4-甲基苯氨基)乙基)乙烷-1,2-二胺，并制备了它的三种过渡金属配合物[ML(H2O)2Cl]Cl (M=CuII，CoII，NiII)，用元素分析、核磁、红外和摩尔电导等表征了配体及其金属配合物的组成和结构。对Ni-L进行了单晶结构解析，配合物为六配位的八面体结构，配体采用三齿配位。利用紫外光谱和荧光光谱法研究了配合物与小牛胸腺DNA的作用方式，结果表明三种金属配合物可能以静电方式与DNA作用。Cu-L、Ni-L、Co-L三种配合物与DNA的结合常数分别为2.99×104、9.78×103、3.66×103。

Abstract:

A novel tridentate ligand (L), N-(4-methylbenzyl)-N′-(2-(4-methylbenzylamino)ethyl) ethane-1,2-diamine and its transition metal complexes [ML(H2O)2Cl]Cl (M=CuⅡ, CoⅡ, NiⅡ) have been synthesized. Their composition and structures were characterized by elemental analysis,1H NMR, FT-IR and molar conductance. The crystal structure of the Ni-L was determined by single crystal X-ray diffraction method. L is a tridentate ligand, which coordinate to Ni atom with 1:1, and all of the complexes have similar six–coordinated octahedral structures. In addition, the interaction of the complexes with calf thymus DNA was investigated by UV spectroscopy and fluorescence spectroscopy, and the results suggested that the complexes may bind to DNA by electrostatic interaction mode. The binding constants (Cu-L, Ni-L, Co-L) are 2.99×104, 9.78×103 and 3.66×103, respectively.