2,5-呋喃二甲酸的合成

Synthesis of furan-2,5-dicarboxylic acid

摘要:

以糠酸为原料，经过酯化、氯甲基化、水解、氧化得到2,5-呋喃二甲酸，并对各步反应中的工艺参数进行了优化。优化结果：酯化反应时间为10 h，氯甲基化反应温度为35~40 ℃，水解反应原料摩尔比为n(氢氧化钠)/n(5-氯甲基-2-呋喃甲酸甲酯) = 2.1 : 1，氧化反应体系pH值为7~8，反应总收率47.5%。按此工艺顺利完成了三次20 L扩试反应，平均收率可达47.3%，纯度大于99.4%。

Abstract:

Furan-2,5-dicarboxylic acid was synthesized from furoic acid by esterification, chloromethylation, hydration and oxidation, the important process parameters in each step was also optimized. The optimal reaction conditions were obtained as follows: the time of esterification was 10 hours, the temperature of chloromethylation was 35~40 ℃, n(sodium hydroxide)/n(methyl 5-chloromethyl- furan-2-carboxylate) = 2.1 : 1 in hydration, pH = 7~8 in oxidation, the total yield was 47.5 %. Under the optimized conditions, the synthetic method of furan-2,5-dicarboxylic acid was successfully carried out three times in 20 L reactor and the average yield could reach 47.3%, and the purity of the product was over 99.4%.