铱催化体系不对称合成手性药物中间体(S)-(-)-1-苯基-1-丙醇

Asymmetric Synthesis of Chiral drug intermediate (S)-(-)-1-Phenyl-1-propanol by Iridium catalytic systems

摘要:

报道了苯丙酮在手性胺膦配体与[IrHCl2(COD)]2组成的铱催化体系下不对称转移氢化合成(S)-(-)-1-苯基-1-丙醇的反应，通过正交实验考察了反应温度，底物/催化剂物质的量之比，金属铬合物/手性配体物质的量之比和碱液浓度对反应的影响。结果表明，在异丙醇中，利用该体系催化苯丙酮反应6 h后，可得到94.5%的转化率和96.0% ee的对映选择性。

Abstract:

The Iridium catalytic systems composed of the [IrHCl2(COD)]2 and the chiral diaminodiphosphine ligand was applied for the asymmetric transfer hydrogenation of propionphenone in synthesis of (S)-(-)-1-phenyl-1-propanol. Influence of temperature, substrate/catalyst molar ratio, metal complex/chiral ligand molar ratio was tested. The 94.5% of conversion and 96.0% ee was achieved when propionphenone was reduced 6 hour in this catalytic system.