硅胶负载磷钼钒杂多酸选择性催化硝化合成5-硝基水杨酸甲酯

Selective synthesis of methyl 5-nitrosalicylate by nitration catalyzed by P-Mo-V heteropolyacid supported on silica gel

摘要:

制备了硅胶负载Keggin型H6PMo9V3O40，并用于催化水杨酸甲酯的硝化反应；考察了反应时间、反应温度、催化剂用量、硝酸用量及催化剂重复使用次数对硝化反应的影响。结果表明，该催化剂对硝化反应具有很高的催化活性和对位选择性，在优化的反应条件下，硝基水杨酸甲酯的产率为94%，p/o为6.58，5-硝基水杨酸甲酯的产率达到81.6%；催化剂回收容易，重复使用5次后，仍有很好的催化活性。

Abstract:

The keggin-type H6PMo9V3O40 on silica gel had be prepared and worked very efficiently with high para selectivity for the mononitration of methyl salicylate with nitric acid using carbon tetrachloride as solvent. The effects of various parameters such as time of reaction, temperature, weight of catalyst and nitric acid had been studied. The yield of methyl mononitrosalicylate was up to 94% with p/o 6.58. The catalyst could be recovered easily and reused for fived times with high catalytic activity.