泰妥拉唑的合成及表征

Synthesis and Characterization of Tenatoprazole

摘要:

摘要：本文以2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐（2）和2-巯基-5-甲氧基咪唑并[4,5-b]吡啶（3）为原料，在氢氧化钠水溶液中30癈下反应生成2-[2-(4-甲氧基-3,5-二甲基)吡啶甲硫基]-5-甲氧基咪唑[4,5-b]吡啶（4），收率90.1%。随后用质量分数为30%的双氧水氧化制得泰妥拉唑（1），收率86.3%，两步总收率为77.8%。产物结构用IR、1HNMR表征，结构正确。

Abstract:

Abstract: 2-[2-(4-methoxy-3,5-dimethyl) pyridlmethylthio]-5-methoxyimidazo [4,5-b] pyridine was prepared with 2-chloromethyl-4-methoxy-3,5-dimethyl pyridine hydrochloride (2) and 2-mercapto-5-methoxyimidazo[4,5-b]pyridine (3) in the solution of sodium hydroxide at 30癈,the yield reached 90.1%. Subsequently, the oxidation of sulfide (3) with hydrogen peroxide of the massfraction of 30% afforded the target compound (1), tenatoprazole. The yield reached 86.3% .The overall yield reached 77.8 %.The structure of the product was characterized by IR, 1HNMR,proved the structure of the product was correct .