TBAFanh.室温氟代脱硝合成对硝基氟苯

Synthesis of p-Nitrofluorobenzene by Fluorodenitration Using Tetrabutylammonium Fluoride at Room-Temperature

摘要:

摘要：研究了以高活性的无水四丁基氟化铵（TBAFanh.）为氟化试剂，在n(PDNB) : n(TBAFanh.) = 1 : 1.2, n(PDNB) = 25 mmol、V(THF) = 10 mL时，室温下实现了对对二硝基苯（PDNB）的选择性亲核氟化，氟代产物收率可达98%以上。反应具有条件温和，产物收率高，副反应少等优点。

Abstract:

Abstract: An efficient method for the synthesis of p-nitrofluorobenzene using highly effective anhydrous tetrabutylammonium fluoride (TBAFanh.) via the fluorodenitration processes is reported. TBAFanh. and p-dinitrobenzene were simply stirred together in an anhydrous solution of THF at room-temperature lead to yields of p-nitrofluorobenzene can reach more than 98%. The nucleophilic fluorinating method has the advantages of surprisingly mild reaction conditions, high yields, easy work-up and little side reaction.