N,N’-二烯丙基二硫代二丙酰胺的合成及抑菌性能研究

Synthesis and antibacterial of N,N’-di-allyl-dithiodipropionamide

摘要:

以β-二硫代二丙酸二甲酯和烯丙基胺为原料通过酰胺化反应合成了N,N’-二烯丙基二硫代二丙酰胺（ALPD），并通过红外光谱（IR）和核磁波谱（1HNMR）对ALPD结构进行表征。探讨了反应物摩尔配比、催化剂用量、β-二硫代二丙酸二甲酯滴加时间、反应时间对ALPD产率的影响；考察了APLD的抑菌性能。结果表明，在固定烯丙基胺为0.3mol前提下最优条件为n（烯丙基胺）:n（β-二硫代二丙酸二甲酯）=3:1，催化剂三乙胺的用量为2.5mL，β-二硫代二丙酸二甲酯的滴加时间为2.5h，反应时间为48h，产率为88.4%。ALPD对大肠杆菌、金黄色葡萄球菌的最小抑菌浓度分别为0.1250g/L、0.0625g/L。ALPD中的双键可以通过聚合反应引入到大分子结构中。

Abstract:

N,N’-di-allyl-dithiodipropionamide(ALPD)has been synthesized with allylamine and dithiodipropionmethyl by amidation , and its structure has been confirmed by IR spectroscopy and 1HNMR. Considering molar ratio of the reactants, amount of the catalyst, dropping time of dithiodipropionmethyl and reaction time impact on the yield of ALPD; researching the antibacterial effects of ALPD. The optimum reaction conditions are n（allylamine）: n（dithiodipropionmethyl）=3:1, the amount of catalyst triethylamin is 2.5mL, dropping time of dithiodipropionmethyl is 2.5h, reaction time is 48h, yield is 88.4%. The MICs of ALPD are 0.1250g/L, 0.0625 g/L with Staphylococcus aureus, Escherichia coli. The ALPD can be introduced into the macromolecular by polymerization.