“一锅法”制备2-芳环取代咪唑化合物

A One-pot Method for the Prparation of 2-Aryl-substituted-imidazoles

摘要:

以氰基取代的芳环化合物为起始原料，采用一锅法经加成、缩合、闭环三步反应合成了六个2-芳环取代咪唑化合物。同时详细考察了反应过程中甲醇钠的用量、闭环反应温度和反应时间对目标产物收率的影响，得到了最佳反应条件：n（甲醇钠）：n（氰基化合物）=（ 0.08～0.12）：1，反应温度为80～90℃，反应时间为3～8 h。产物的结构通过熔点、核磁、质谱、元素分析进行了确证。

Abstract:

Six 2-aryl-substituted imidazoles were prepared from corresponding nitriles, which was reacted with aminoacetaldehyde dimethyl acetal through three steps by one-pot method. From study on the effects of sodium methoxide amount, temperature and time of cyclization reaction, the optimum conditions were investigated that the mole ratio of the amount of sodium methoixde to the starting nitriles was ( 0.08～0.12): 1, the cyclization reaction temperature was 80～90℃ and the cyclization reaction time was 3～8 h. The structures of all products were characterized by melting point, Mass, 1HNMR and elemental analysis.