2-氯-6-甲氧基-9-烷基嘌呤化合物的合成

Synthesis of 2-Chloro-6-methoxy-9-alkylpurine Compounds

摘要:

以2-氨基-6-氯嘌呤为原料，通过烃基化反应、重氮化反应和烷氧基化反应，得到2-氯-6-甲氧基-9-烷基嘌呤化合物，其结构经MS、1H NMR和元素分析等方法确认。探讨了溶剂选择、原料配比、催化剂和反应温度等因素对N9-烃基化反应的影响，其最优反应条件为：以DMF为溶剂，碳酸钾为缚酸剂，苄基三乙基氯化铵为相转移催化剂，n (2-氨基-6-氯嘌呤) : n (溴代烷)=1:3, n (溴代烷): n (碳酸钾)=1:1.5，与碳酸钾等当量的苄基三乙基氯化铵，反应温度为20℃，烃基化反应收率可达76%以上。

Abstract:

An efficient procedure for the alkylation, diazotization and oxyalkylation of 2-amino-6-chloropurine to 2-Chloro-6-methoxy-9-alkylpurine compounds in good to excellent yield is reported. The synthesized compounds were characterized by MS, 1H NMR and elemental analysis. The effects of solvent, mole ratio of raw material, catalyst and reaction temperature on the alkylation reaction were discussed, and the yields of the compounds of this step were more than 76% under optimized conditions that n (2-amino-6-chloropurine): n (bromoalkane) = 1:3, n (bromoalkane): n (K2CO3) = 1:1.5, reaction temperature was 20℃ with DMF as solvent.