2-氟-5-溴硝基苯的合成

Synthesis of 2-fluoro-5-bromonitrobenzene

摘要:

采用冰醋酸作为溶剂，以邻氟硝基苯为原料， N-溴代丁二酰亚胺(NBS)为溴代试剂，合成了2-氟-5-溴硝基苯。所得目标产物通过GC-MS定性、GC定量检测。结果表明，最佳反应条件为邻氟硝基苯:NBS（摩尔比）=1:1.05，以冰醋酸作溶剂，温度10 ℃，反应2 h，在此条件下2-氟-5-溴硝基苯的收率为98.6%，原料转化率100%。该反应条件温和，易于控制，重复性好。

Abstract:

2-fluoro-5-bromonitrobenzene was prepared from 2-fluoronitrobenzene using the solvent acetic acid (CH3COOH) instead of sulfuric acid or 2-fluoro-5-bromonitrobenzene was prepared from 2-fluoronitrobenzene using the solvent acetic acid (CH3COOH) instead of sulfuric acid or boron trifluoride, using N-bromosuccinimide (NBS) as bromide reagent. The reaction condition was mild and easy to be controlled, the target product qualitative was analysised by GC-MS and quantification was analysised by GC. The best yield(98.6%) of 2-fluoro-5-bromonitrobenzene and conversion (100%) of 2-fluoronitrobenzene were obtained under optimized conditions that n(2-fluoronitrobenzene):n(NBS) =1:1.05, the reaction temperature was 10 ℃ and the reaction time was 2 h. The repeat experiments showed that the technology had a good repeatability under above optimum conditions.