二硫代二丙酰胺衍生物的合成及其抑菌性能与防污性能研究

Synthesis of dithiodipropionamide derivatives and Study of their bacteriostatic and antifouling properties

摘要:

以丙烯酸甲酯为原料，经过二硫代反应、酯的氨解反应，得到N’N-二丁氧基丙基二硫代二丙酰胺(BPD)、N’N-二甲氧基丙基二硫代二丙酰胺(MPD)、 N’N-二正辛基二硫代二丙酰胺(OLPD)三种二硫代二丙酰胺衍生物，利用红外和核磁表征其结构。三种化合物分别对大肠杆菌和金黄色葡萄球菌进行抑菌实验，结果表明三种受试化合物对大肠杆菌、金黄色葡萄球菌均具有较好的抑制作用，抑制效果BPD≈MPD>OLPD。BPD对二种菌株的MIC值可达0.0625 mg/mL。将所得化合物制备成涂料，通过海上挂板实验研究其防污性能；海上挂板结果表明：三种化合物都具有较好的防污作用，防污效果BPD>MPD>OLPD。

Abstract:

Three dithiodipropionamide derivatives , N’N-dimethoxypropyl- dithiodip- ropionamide（MPD）,N’N-dibutoxypropyl-dithiodipropionamide (BPD),N’N-dinoctyl- dithiodipropionamide（OLPD）were synthesized from methyl acrylate in the aqueous phase and detected by infrared spectrometer and NNR spectrometer. The bioassay results showed that all the three compounds possessed good antibacterial activities, with MIC value of BPD to Escherichia Coli and Staphylococcus aureus reached 0.0625 mg/mL.Then the compounds were put into paintings made them antifouling paintings. The study of their antifouling properties by submerging in the ocean showed that they all have good qualities of antifouling. The BPD showed the best antifouling property.