5-氯甲基水杨醛的清洁制备方法

The Green Preparation of 5-Chloromethylsalicylaldehyde

摘要:

以水杨醛、多聚甲醛和浓盐酸为原料，实验研究了三氯氧磷在制备5-氯甲基水杨醛中的应用。实验结果表明，当三氯氧磷的用量是水杨醛质量的30%，控温15~25℃，搅拌反应28h时，5-氯甲基水杨醛的收率可达92%以上；三氯氧磷作为氯甲基化反应中氯化氢的供源的同时也可作为反应母液的再生剂，显著降低了废酸排放量；相比文献报道，本文制备5-氯甲基水杨醛的原料成本降低了25%左右。

Abstract:

5-Chloromethylsalicylaldehyde was synthesized from salicylaldehyde, paraformaldehyde and concentrated hydrochloric acid as the raw materials and used with phosphorus oxychloride. The result showed that the yield of 5-chloromethylsalicylaldehyde reached 92% when the quality of phosphorus oxychloride is 30% of the salicylaldehyde, 15~25℃, 28h, stirred. Phosphorus oxychloride was not only used as the source of hydrogen chloride in the chloromethylation reaction, but also the regeneration for the mother liquor, which reduced the discharge value of waste acid. The raw materials cost to synthesize 5-chloromethylsalicylaldehyde reduced 25% compared to the references.