聚甲基丙烯酸-介孔氧化硅复合材料的制备及释药研究

Preparation and Drug Release Performance of Polymethacrylic Acid-Mesoporous Silica Composite

摘要:

采用自由基聚合的方法合成了pH敏感性聚甲基丙烯酸(PMAA)/介孔分子筛SBA-15纳米复合物。用XRD、FT-IR、TG、低温N2吸附-脱附、TEM等手段对复合物进行了表征,并以阿司匹林为模型药物分子，进行了药物释放测试。结果表明,复合材料仍然保持有序六方结构，但比表面积、孔容、孔径有所降低； 在pH=7.4的释放介质中，12h内释放了72%的药物，而在pH=1.0的释放介质中，12h药物释放量为30%。这种纳米复合材料对阿司匹林的释放具有pH敏感性，有望在药物控制释放领域得到应用。

Abstract:

The pH-sensitive mesoporous nanocomposite PMAA/SBA-15 was synthesized by free radical polymerization.The nanocomposite was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy,thermogravimetric analysis,transmission,N2 adsorption-desorption and electron microscopy.With Aspirin as model drug, the drug release behavior of the composite was studied. It was found that the composite remained ordered hexagonal structure, but the surface area, the pore volume and the pore size of the composite were decreased. In the release medium of pH=7.4 the release of Aspirin was much quicker than pH=1.0.Therefore, the release of Aspirin from the nanocomposite could be controlled by changing pH. The PMAA/SBA-15 composite has a potential application in drug release.