季铵化两亲性壳聚糖衍生物载药性质研究

Characterization and Drugdelivery Behavior of Quaternary Amphiphilic Chitosan Derivatives

摘要:

合成新型季铵化两亲性壳聚糖衍生物(DEAE-CMC)。用乳化交联固化法制备DEAE-CMC/VB12载药微球。用激光粒径仪、扫描电镜对微球的大小和形态进行表征。载药微球的平均粒径为4.53 μm。在pH=7.4磷酸盐缓冲溶液中，DEAE-CMC/VB12载药微球体外药物释放达到平衡时间为60 h，药物包封率为33.70 %，载药量为12.47 %，平衡时药物累积释放率为56.30 %。

Abstract:

A series of novel quaternary amphiphilic chitosan derivatives(DEAE-CMC)were prepared.The DEAE-CMC/VB12 microspheres were prepared by “Emulsion—Crosslinking—Solidification” method. The partical size, topography and microstructure of the microspheres were analyzed by laser particle size analyzer and scanning electron microscopy (SEM).The result showed that the average partical size of the DEAE-CMC/VB12 microspheres was 4.53 μm。The drug release behavior of the DEAE-CMC/VB12 microspheres in pH=7.4 phosphate buffer solutions showed that: the release equilibrium time was 60 h, the entrapment efficiency was 33.70 ,and the loading content was 12.47 %. At the equilibrium, the accumulated release ratio of the drug was 56.30 %.