1, 2-苯并-异噻唑啉-3-酮与锌(Ⅱ)、铜(Ⅱ)配合物的合成及其抑菌性

Synthesis and Antibacterial activity of Complexes based on 1, 2-benzoisothiazolin-3-one

摘要:

利用1, 2-苯并-异噻唑啉-3-酮（BIT）与醋酸锌、醋酸铜反应得到配合物，[Zn(BIT-H)2] (1)，[Cu(BIT)(BIT-H)(CH3COO)] (2)；利用红外衍射、元素分析、紫外可见分析、核磁共振分析等手段对配合物结构进行分析和表征。将所得的配合物1和配合物2分别做抑菌试验，它们对大肠杆菌的最小抑菌浓度分别是：2.344?0-3 mg/mL，1.172?0-3 mg/mL，对金黄色葡萄球菌的最小抑菌浓度分别是：1.172?0-3 mg/mL，1.172?0-3 mg/mL，配合物的杀菌性很好。

Abstract:

Reacted of gramine remification 2-benzoisothiazolin-3-one (BIT) with Copper acetate and Zinc acetate obtained two organic/inorganic complexes: [Zn(BIT-H)2] (1), [Cu(BIT)(BIT-H)(CH3COO)] (2). the structures of the complexes were characterized by EA, IR, 1H NMR and UV-Vis, Antibacterial experiments of the two complexes were studied, The MIC of the two complexes with Escherichia coli : 2.344?0-3 mg/mL, 1.172?0-3 mg/mL. The MIC of the two complexes with Staphylococcus aureus: 1.172?0-3 mg/mL, 1.172?0-3 mg/mL.