取代1,3-二苯基-1,3-丙二酮的合成与抗氧化性能研究

Study on Synthesis and Antioxidant Activity for different substituted 1,3-diphenyl-1,3-propanedione

摘要:

以取代芳酮和取代芳酯经克莱森反应合成了5个取代1,3-二苯基-1,3-丙二酮。采用4因素3水平正交试验优化1,3-二(4-甲氧苯基)-1,3-丙二酮较佳的工艺条件：以甲苯为溶剂，NaNH2作催化剂，n(对甲氧基苯乙酮)：n(对甲氧基苯甲酸甲酯)：n(氨基钠)=1:4:5，微波辐射功率320W，反应时间45min,收率为72.1%。合成的产物结构经IR与1HNMR光谱进行结构表征，用HPLC测定含量。对UV光谱有良好的吸收及对猪油有较好的抗氧化作用

Abstract:

A series of para-substituted 1,3-diphenyl-1,3-propanedione compounds have been synthesized by the Claisen condensation reaction of different substituted aromatic ketone and ester. Experiment based upon orthogonal design with four factors and three levels was carried out for optimization of conditions for 1,3-bis-(4-Methoxy-phenyl)-1,3-propanedione. Experimental results showed the suitable conditions as follows：using toluene as solvent and sodium amide as catalyst, n(p-methoxy acetophenone):n (methyl-p-methoxybenzoate):n (sodium amide ) = 1:4:5. microwave irradiation power was 320W and reaction time 45min. The yield can achieve 72.1%.The structures of synthetic products were characterized by IR and 1HNMR .HPLC was selected to determine the concentration of products. The products are good UV ultraviolet absorbents and exhibit significant antioxidation activity on lard..