催化环氧乙烷氢甲酯化的催化体系研究

Study on the Catalysis System for Ethylene Oxide Hydroesterification

摘要:

实验以Co2(CO)8为催化剂，甲醇为溶剂，在一定的CO压力下，催化环氧乙烷氢甲酯化合成3-羟基丙酸甲酯。考察了不同配体、催化剂/配体的比例、温度、CO压力、甲醇的量对环氧乙烷氢甲酯化反应的影响。得到较佳的合成工艺条件是：咪唑为配体、n(催化剂)/n(配体)=1:1.5、反应温度75℃、反应压力6.0MPa、V(甲醇):V(环氧乙烷)=5:1为最优的反应条件。在此优化条件下，环氧乙烷的转化率为92.24%，3-羟基丙酸甲酯的收率达到84.35%。

Abstract:

Methyl 3-hydroxypropanoate was synthesized by hydroesteri- fication of ethylene oxide with carbon monoxide in the presence of Co2(CO)8 catalyst and methanol solvent. The influences of different ligands, catalyst/ligand molar ratio，reaction temperature, CO pressure, and methanol dosage in the system on the reaction were investigated. The results revealed that imidazole was a good ligand for the reaction and the optimal reaction conditions were catalyst/ ligand molar ratio1:1.5, reaction temperature 75℃, CO pressure 6.0MPa, methanol/(ethylene oxide) volume ratio 5:1. Under the optimal conditions, the conversion of ethylene oxide was 92.24%, the yield of methyl 3-hydroxypropanoate was 84.35%.