醋酸羟丙基甲基纤维素琥珀酸酯的合成

Synthesis of hydroxypropyl methylcellulose acetate succinate

摘要:

摘要：以羟丙基甲基纤维素（HPMC）为原料，琥珀酸酐，乙酸酐为酯化剂，在醋酸中通过酯化反应制备了醋酸羟丙基甲基纤维素琥珀酸酯（HPMCAS）。通过改变影响基团含量的各种因素条件，得到了不同取代度的产物。采用滴定法测定了琥珀酰基、乙酰基的含量，并对产品结构进行表征和性能测试。结果表明：该反应体系在 105oC 反应 6.5 h，反应后选用去离子水为沉淀剂，机械搅拌（750rpm）使产物沉析，可得到琥珀酰基和乙酰基含量分别为 13% 和 8% 左右的产品。获得的产品HPMCAS多分散系数为 1.06，分子量分布较窄，在丙酮、甲醇等溶剂中表现出良好的溶解性能，并在 200oC之前对热稳定。

Abstract:

Abstract: Hydroxypropyl methylcellulose acetate succinate (HPMCAS) was successfully synthesized from hydroxypropyl methylcellulose (HPMC), which was used succinic anhydride and acetic anhydride as esterifying agent, acetic acid as organic solvent. By varying the amount of factors, HPMCAS with the different content of succinyl groups and acetyl groups were prepared. The contents were determined by titration, and then the structure of the product was characterized and tested. The results show that the reaction system was heated at 105oC for 6.5 h, after reaction we use deionized water for the precipitation agent, make products precipitated in 750 rpm speed. We can obtain that the succinyl groups and acetyl groups were about 13% and 8% respectively. The obtained HPMCAS products have the polydispersity index of 1.06 and the molecular weight distribution is narrow. The product has a good solubility in acetone, methanol and other solvents and the thermal stability is very good before 200 oC.