水杨酸壳聚糖/卵磷脂纳米粒的制备

Preparation of salicylic acid-loaded lecithin/chitosan nanoparticles

摘要:

摘要：采用溶剂注入法制备水杨酸壳聚糖/卵磷脂纳米粒。考察粒子结构、形貌特征、粒径分布及表面电位等性能，并探讨制备工艺对药物包封率的影响。确定最佳制备工艺为卵磷脂浓度20mg/mL、卵磷脂与壳聚糖、水杨酸与载体质量比分别为3∶1和1∶6、水相pH为4。所制备的水杨酸壳聚糖/卵磷脂固体纳米粒子为球形粒子、表面电位 18.7mV、平均粒径为150nm、包封率及载药量可分别达到55%和8.07%。该纳米粒子制备方法可为开发脂溶性美白活性化妆品制剂提供新的途径。

Abstract:

Abstract: The salicylic acid-loaded lecithin/chitosan nanoparticles were prepared by Solvent injection method. The structure, morphology, size distribution as well as surface potential of nanoparticles were investigated. Finally the effects of preparation technology on drug entrapment efficiency by using the dialysis technique were also studied. The preparation process adapted to the formulation was as follows：the concentration of lecithin was 20mg/mL, lecithin-chitosan and SA-carriers weight ratios were 3:1(w/w) and 1:6(w/w) respectively, the pH of Water phase reaches 4. The average diameter of optimized spherical nanoparticles was 150nm with good encapsulation efficiency and drug loading up to 55% and 8.07% respectively, the Zeta potential was 18.7mV. The preparation method of salicylic acid-loaded lecithin/chitosan nanoparticles may provide a new approach for the development of fat-soluble whitening active ingredients-loaded delivery.