γ-丁内酯乙氧基化合成内酯冠醚

Synthesis of lactonic crown ethers by ethoxylation of γ-butyrolactone

摘要:

以Al-Mg基复合氧化物为催化剂，尝试采用环氧乙烷（EO）分子插入γ-丁内酯（GBL）的新反应合成内酯冠醚，用FT-IR和ESI-MS对目标产物结构进行了确证。实验结果表明LE-4催化剂的催化效果最佳；对反应温度和压力的优化实验进一步表明，当使用1 %(w/w)的LE-4催化剂，EO与GBL的物质量比为5时，优化反应温度和体系压力分别为160 oC和0.65 MPa，GBL转化率达到75.2%。

Abstract:

Lactonic crown ethers were synthesized by a novel insertion reaction of ethylene oxides into γ-butyrolactone (GBL) catalyzed by Al-Mg composite oxide, and the molecular structures of the target products were confirmed by FT-IR and ESI-MS. The process was optimized with respect to Al/Mg molar ratio of catalysts, reaction temperature and pressure. The conversion of GBL was 75.2% when the insertion reaction was catalyzed by 1 %(w/w) of LE-4 catalyst based on the target products and run in 5 times molar ratio of EO to GBL at160oC under 0.65 MPa.