新型蓖麻油基季铵盐的合成及其抑菌性能研究

Synthesis and Antitumor Activity of Novel Castor Oil-Based Quaternary Ammonium

摘要:

摘要：以蓖麻油酸甲酯为起始原料，通过胺解反应和季铵化反应生成了新型蓖麻油基季铵盐，其结构经红外光谱（FTIR）、氢谱（1H NMR）、碳谱（13C NMR）及电喷雾电离质谱（ESI-MS）确证。采用抑菌圈直径法对目标产物的抑菌性能进行了测试，研究结果表明：蓖麻油基季铵盐均有一定的抑菌活性，N,N-二甲基-N-乙基-蓖麻油酸酰胺丙基溴化铵的抑菌活性略强于N,N-二甲基-N-苄基-蓖麻油酸酰胺丙基溴化铵。

Abstract:

Abstract: Two novel castor oil-based quaternary ammonium were synthesized from the starting material of methyl ricinoleate by aminolysis reaction and quaternization reaction. Their structures were characterized by means of FTIR, 1H NMR, 13C NMR and ESI (MS) . Bactericidal activity of novel castor oil-based quaternary ammonium salts were evaluated by inhibitory zone diameters against E. coli and S. aureus. It was found that castor oil-based quaternary ammonium salts have antibacterial activity. Antibacterial activity of the N, N-dimethyl-N-ethyl-castor oil acid amide propyl bromide than N-benzyl-N, N-dimethyl-castor oil acid amide propyl bromide.