响应面法优化微胶囊复合壁材配比的研究

Optimization of the Composite wall material of Microencapsulation by Response Surface Methodology

摘要:

壁材作为微胶囊的重要组成部分，决定微胶囊的特性。本文选择海藻酸钠等为壁材，采用高压静电微胶囊制备装置，以成囊合格率为检测指标，运用Box-Behnken中心组合设计和响应面分析，研究了壁材配比对微胶囊特性的影响。得到的最优壁材配比为1.53%海藻酸钠，4.52%聚乙烯醇，1%明胶，1%甘油，成囊溶液氯化钙浓度为22.86g/L，微胶囊合格率为87.37%。可为食品、医药、化工等微胶囊化壁材配比选择提供参考。

Abstract:

The wall material which is an important part of the microencapsulation,determines the characteristics of the microencapsulation. In this paper，the wall materials were sodium alginate etc , the high-voltage electrostatic microcapsule forming device was used , the qualified rate was chosen as the indicator, the Box-Behnken central composite design and response surface analysis were used, the main factors which affect the microcapsules were regression modeling and optimization. The optimal wall materials were 1.53% of sodium alginate, 4.52% of polyvinyl alcohol , 1% of gelatin content, 1% of glycerol , the 22.86g/L of encysted solution of calcium chloride ,and the qualified rate of microencapsulation was 87.37%. The special stability and strength of wall material ratio which provide reference for the microencapsulation of food, medicine were obtained.