Pd(PPh3)4催化Suzuki偶联反应合成4-溴-2-氟-联苯

Synthesis of 4-bromo-2-fluorobiphenyl by SuzukiCoupling Reaction with Pd(PPh3)4 Catalysis

摘要:

摘要：以苯硼酸和2-氟-4-溴碘苯为起始原料，经Suzuki偶联反应合成了纯度99.5%以上的医药和液晶中间体4-溴-2-氟-联苯，目标化合物进行了1HNMR、IR和GC-MS表征。探讨了硼酸自偶及三联苯副产物产生的原因，并对副产物产生的机理进行了推测。

Abstract:

Abstract：More than 99.5% purity of medicine and liquid crystal intermediate of 4-bromo-2-fluorobiphenyl was synthesized via Suzuki coupling reaction with phenyl boric acid and 2-fluoro-4-bromo-iodobenzene as starting materials.The target compound was characterized by 1HNMR、IR and GC-MS. The generation cause of the by-product of boric acid self-coupling and terphenyl by-product was investigated, and the generation mechanism of by-products was speculated.