含二茂铁基的酰肼化合物的合成

Synthesis of Hydrazide Compounds Containing Ferrocene

摘要:

以二茂铁二甲酰氯和芳甲酰肼为原料，用微波法合成了9个N2,N2，-二芳甲酰基-1,1，-二茂铁二甲酰肼类化合物 3，并通过IR、1H NMR和ESI/MS对其结构进行了表征。紫外光谱研究表明，含吸电子取代基的化合物3f 对阴离子F-、CH3COO-有识别作用，化合物3h、3i对F-、CH3COO-、H2PO4-有识别作用。初步的生物活性测试表明，取代基位于邻位的化合物3a、3b和3c对金黄色葡萄球菌、大肠杆菌有良好的抑菌作用。

Abstract:

Nine novel compounds 1,1，-bis[(2-benzoylhydrazinyl)carbonyl]-ferrocene 3 were obtained from chlorocarbonyl ferrocene and aromatic formyl hydrazine by using microwave method. The structures of the title compounds have been determinded by IR, 1H NMR and ESI/MS techniques. The studies on the UV-Vis absorption spectroscopies show that the anion receptor 3f have selective recognition for F-, CH3COO-, and 3h, 3i for F-, CH3COO-, H2PO4-. Preliminary biological activity test show that ortho-substituted compounds 3a, 3b and 3c have bacteriostatic action to staphylococcus aureus, escherichia coli.