稳定同位素标记恩诺沙星-D5的合成

Syntheses of Labeled Enrofloxacin-D5

摘要:

以乙醇-D6为合成前体，与碘反应得到碘乙烷-D5，再进一步与环丙沙星烷基化生成恩诺沙星-D5，以消耗的乙醇-D6计算，恩诺沙星-D5总收率为69.9%。产品结构经质谱和核磁共振波谱等表征确定，纯度为99.0%，同位素丰度为99.6%，可作为食品安全领域检测用同位素内标试剂。

Abstract:

This article presents efficient synthesis of labeled standard Enrofloxacin-D5，with CD3CD2OD as the common substrate．Iodonation of CD3CD2OD with I2 provided CD3CD2I，which was subsequently used to ethylate Ciprofloxacin to get Enrofloxacin-D5。The yield of Enrofloxacin-D5 was 69.9% based on CD3CD2OD consumed．The product was confirmed by NMR and LC-MS to be target compound．Its chemical purity was 99.0% and isotopic enrichment was 99.6 %．It could be used as internal standard in the field of food safety testing．