希夫碱配体结构的改变对Cu（Ⅱ）SOD模拟物的抗氧

Structural Modification of Salen-type Schiff-base Ligands on the Superoxide Dismutase (SOD) Activity of Their Cu(II) Complexes

摘要:

在希夫碱Cu(II)配合物1 (Cu(II)双香草醛缩乙二胺)、4 (Cu(II)双香草醛缩邻苯二胺)的基础上，对配体结构进行了设计，将重原子效应、共轭效应、空间位阻效应等结构影响因素引入到SOD(超氧化物歧化酶)模拟物的结构设计中，合成了4种希夫碱类铜金属配合物，并用X 射线单晶衍射法测定了配合物2的晶体结构。运用改进的NBT还原法测定了这6种SOD模拟物的抗氧化活性，结果表明：结构改变后的SOD模拟物较原结构配合物的抗氧化活性均有明显的提高且各因素影响幅度有所不同。

Abstract:

The functional effect factors (conjugation, heavy-atom or steric effect) were used to design and synthesis four Cu(II) complexes based on Schiff-base Cu(II) complexes 1 (Cu(II) with N,N’-bis (3-methoxy-salicylidene)ethlene-1,2-diamine) and complexes 4 (Cu(II) with N,N’-bis(3-methoxy-salicylidene)phenylene-1,2-diamine). The structure of complex 2 was characterized by X-ray diffraction analysis. Furthermore, using NBT illumination method to determine those anti-oxidant activities, the result shows that, after changing structure, the anti-oxidation activity of complexes has been improved significantly. Additionally, several factors definitely influence the activity but the degree of influence were different.