一氯三嗪-β-环糊精包络晚香玉香精纳米粒的制备及表征

Preparation and Characterization of Tuberose Fragrance-Loaded MCT-β-CD Nanoparticles

摘要:

摘要：以一氯三嗪-β-环糊精（MCT-β-CD）为壁材，晚香玉香精为芯材，通过包络法制备一氯三嗪-β-环糊精晚香玉香精纳米粒。研究了壁材与芯材的质量比、乙醇与水的体积比、反应时间、反应温度、搅拌速度对晚香玉香精纳米粒粒径的影响，并采用动态激光光散射仪（DLS）、透色电镜（TEM）、红外光谱（IR）及热重分析仪（TGA）对其结构及性能进行了表征。结果表明，在 v(乙醇)：v(水) = 1:0.7，m(香精)：m(壁材) = 1:15，反应时间10h，搅拌速度1300rpm，温度为35℃的条件下制备的晚香玉香精-一氯三嗪-β-环糊精纳米粒的粒径为216.4nm，粒径分布系数(PDI)为0.221，香精装载量达17.2%，能减缓高温下香精的释放速率。

Abstract:

Abstract: Tuberose fragrance loaded monochlorotriazinyl-β-cyclodextrin(MCT-β-CD) nanoparticles were prepared by the inclusion complexation method. The effects of the volume ratio between athenol and water, the mass ratio between tuberose and MCT-β-CD, the reaction time , the stirring rate and the reaction temperature to the size distribution of tuberose fragrance-loaded MCT-β-CD nanoparticles were investigated. The tuberose fragrance-loaded MCT-β-CD were characterized by dynamic light scattering(DLS), Transmission electron microscope( TEM ), Infrared Spectrometer ( IR ) and Thermogravimetric Analyzer ( TGA ). Results showed that the particle size was 216.4 nm, the polydispersity index(PDI) was 0.221 and the fragrance loading capacity was 17.2% when v(CH3CH2OH): v(H2O) = 1:0.7, m(fragrance): m(Wall Materials) = 1:15, reaction time was 10 h, rotational speed was 1300rpm and reaction temperature was 35℃. The release rate of tuberose fragrance-loaded MCT-β-CD nanoparticles was decreased under the high temperature.