琥珀酰基月桂酰壳聚糖的制备及性能
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The preparation and properties of lauroyl-succinyl chitosan
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    摘要:

    以丁二酸酐和壳聚糖(CS)为原料合成亲水性的琥珀酰基壳聚糖(SCS),然后以月桂酰氯为烷基化试剂,通过酰化反应制备了两亲性的琥珀酰基月桂酰壳聚糖(LSCS)。采用FTIR和1H-NMR对壳聚糖衍生物进行了结构的表征。LSCS的琥珀酰基的取代度为41.27%,月桂酰基的取代度为6.32%。改性后的壳聚糖在pH<3.0和pH>6.5时溶解度较好,在等电点及附近的pH范围内溶解度降低。LSCS具有较强的分子间相互作用,随浓度增加溶液粘度显著增加,且在浓度达到2wt%时可形成物理凝胶。该物理凝胶对NaCl浓度较敏感,随着NaCl浓度的增加,凝胶强度减小。

    Abstract:

    A new type of amphiphilic chitosan was synthesized by the attachment of succinyl group and lauroyl group to the CS backbone. Modification was confirmed by FTIR and 1H-NMR.The degree of succinyl,substitution was 41.27%, and the degree of lauroyl substitution was 6.32%. Lauroyl-succinyl chitosan (LSCS) can dissolved at pH<3.0 and pH>6.5,and its solubility decreased in isoelectric point and nearby pH range. The LSCS with long alkyl chain can aggregate in water solution through inter-molecular interaction, so their solutions viscosity increased significantly with the increasing of concentration, and as their concentration was up to 2wt%,, it presents gel-like behavior. The gel was sensitive to NaCl. As the concentration of NaCl increased, the strength of gel decreased.

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张艳飞,杨成.琥珀酰基月桂酰壳聚糖的制备及性能[J].精细化工,2013,30(1):

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  • 收稿日期:2012-10-16
  • 最后修改日期:2012-11-09
  • 录用日期:2012-12-05
  • 在线发布日期: 2013-01-07
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