2,4-二氨基苯基胆甾醚的合成

Synthesis of 2,4-Diaminophenyl Cholesteryl Ether

摘要:

以溴苯为原料，经硝化后，在四丁基溴化铵作相转移催化剂作用下与胆固醇成醚、硝基还原反应得到2,4-二氨基苯基胆甾醚，并对成醚反应的条件进行了优化。较佳合成反应条件是：以甲苯为溶剂，n(2,4-二硝基溴苯): n(胆固醇)=1.55 : 1，反应温度25℃，NaOH的质量分数为w =50 %，反应时间3.5h，产率为72%。所得中间体和目标化合物经过了红外和核磁波谱的表征。

Abstract:

Using bromobenzene and cholesterol as starting materials, 2,4-diaminophenyl cholesteryl ether was synthesized by nitration, reduction and etherification reactions. The optimum reaction conditions of etherification were determined. The preferred reaction conditions are : n(2,4-dinitrobromobenzen):n(cholesterol)=1.55:1, w (NaOH)=50% , reacting for 3.5h at 25℃ with Toluene as solvent. The yield of 2,4-diaminophenyl cholesteryl ether (C) is 72%.The structures of all products were characterized by IR and 1H NMR spectra.