新型二羟基手性磷酸催化剂的合成

Synthesis of newly chiral phosphoric acid catalyst carrying two hydroxyls

摘要:

以 (R)-BINOL(1,1’-联二萘酚)为原料，在n-BuLi的作用下对BINOL的3,3位上进行修饰，获得(R)-3,3’-双(二苯基羟基)-2,2’-二羟基-1,1’-联二萘酚1c，并通过羟基选择性保护，磷酸化反应，将其转化为具有潜在能力的手性磷酸催化剂2a,收率52%。

Abstract:

The intermedia 1c of (R)-3,3’-Bis(diphenylhydroxyl)-2,2’-dihydroxy[1,1’] binaphthalenyl had been obtained by modification of (R)-BINOL at 3,3’ positions under the interaction of n-BuLi, and then had been converted successfully into the potent axially dissymmetric binaphthyl phosphoric acid 2a through selective hydroxyls protection, and phosphonation. The yield arrived to 52%.