R-3,5双三氟甲基苯乙醇不对称合成工艺研究

Research on asymmetric synthesis of R-3, 5 (trifluoro-dimethyl) benzene ethanol

摘要:

以[RuCl2(C10H14)2]2为催化剂、(1S,2R)-(-)-1-氨基-2-茚醇为配体，3,5-双三氟甲基苯乙酮在异丙醇中发生不对称氢化还原反应得到R-3,5双三氟甲基苯乙醇。反应时间6h、温度50℃、催化剂和配体的比1:2.5、底物浓度0.0957mol/L时得到产品的转化率99%，选择性(ee)91.2%。并用FT-IR和1H NMR进行了表征。

Abstract:

A asymmetric transfer hydrogenation to synthesize R-3,5-(trifluoro-dimethyl) benzene ethanol from 3,5-Bis(trifluoromethyl)acetophenone in isopropyl alcohol by using [RuCl2(C10H14)2]2 as catalyst and (1S, 2R) - (-) - 1 - amino - 2 - indene alcohol as ligands was discussed in this paper,reaction time 6h, reaction temperature 50℃, catalyst/ligands ratio 1:2.5, Substrate concentration 0.0957mol/L, The conversion rate of the product was 99%. Selective(ee) was 91.2% The target product was characterized by means of FTIR and 1H NMR．