十二烷基胍盐酸盐的合成与性能

Synthesis and properties of dodecylguanidine hydrochloride

摘要:

一步合成了十二烷基胍盐酸盐表面活性剂，经单因素实验确定了较佳工艺条件，95%乙醇为溶剂，n（十二胺）∶n（氰胺）∶n（盐酸）=1∶1.5∶1.1，反应时间2h。产品通过IR、1H-NMR和元素分析进行了结构分析，并对其表面活性、泡沫性、乳化性和抑菌性能进行了测试。结果表明，十二烷基胍盐酸盐的cmc为5.5mmol/L，最低表面张力为24.1mN/m，与DTAC相比，具有较好的泡沫性能，较差的乳化能力，较强的抑菌活性，在25mg/L浓度下对金黄色葡萄球菌和大肠埃希氏菌的抑菌率达100%，在100mg/L浓度下对白色念珠菌的抑菌率达99.5%。

Abstract:

A cationic surfactant dodecylguanidine hydrochloride was synthesized and the optimized reaction conditions were: n(dodecylamine)∶n(cyanamide)∶n(hydrochloride)=1∶1.5∶1.1, refluxed for 2h in ethyl alcohol solvent. The structure of product was confirmed by IR, 1H-NMR and elemental analysis. The properties of the product were measured, such as surface activity, foaming and emulsifying power, and antimicrobial capacity. Results showed that cmc of the product is 5.5mmol/L, γcac is 24.1mN/m. The product had better foaming and lower emulsifying abilities than DTAC. The inhibitions of cell viability for Staphylococcus aureus and Escherichia coli are 100% at the concentration of 25mg/L and for Candida albicans is 99.5% at the concentration of 100mg/L respectively.