2-(4,6-二甲氧基嘧啶-2-基)-8-(4,6-二甲氧基嘧啶-2-氧基)-3,4-二氢异喹啉-1(2H)-酮的合成

Synthesis of 2-(4,6-dimethoxypyrimidin-2-yl)-8-(4,6-dimethoxypyrimidin-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

摘要:

为了发现具有生物活性的新型分子结构，以具有除草活性的化合物结构为基础，根据类同合成法，以苯酚和3-氯丙酰氯为原料进行缩合反应生成3-氯丙酸苯酯，后经环化、酰化及取代反应合成了化合物2-(4,6-二甲氧基嘧啶-2-基)-8-(4,6-二甲氧基嘧啶-2-氧基)-3,4-二氢异喹啉-1(2H)-酮。化合物的分子结构经核磁共振谱、质谱和元素分析进行了表征。

Abstract:

The purpose of the study was looking for the novel compounds with biological activities. Based on the structure of the compounds with herbicidal activity, according to analogue synthesis, phenyl 3-chloropropanoate was synthesized using phenol and 3-chloropropanoyl chloride as starting materials by condensation reaction. Then 2-(4,6-dimethoxypyrimidin-2-yl)-8-(4,6-dimethoxypyrimidin-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one was synthesized by cyclization reaction, acylation reaction and substitution reaction respectively. The compound was confirmed by 1H NMR, MS and elemental analysis techniques.