两个Ga环五肽类似物的合成及研究

Study on synthesis of two novel pentapeptides Galaxamide Analogues

摘要:

本文以Leu和Phe为起始原料，改变其环合位点，优化其合成路线，合成了两个GA类似物，其环合收率达近50%。使用反相HPLC进行分离纯化，通过1H-NMR、13C-NMR和MS对其结构进行表征。

Abstract:

Two new pentapeptides were totally synthesized using Leucine and Phenylalanine as starting materials, through changing cyclic sites and optimizing the route of synthesis. The yield of cyclization reation was nearly up to 50%. The products were purified by RP-HPLC, and the compound structures were characterized by 1H-NMR, 13C-NMR and MS.