2-溴-6-氟甲苯衍生物的合成

Synthesis of 2-Bromo-6-Fluorotoluene derivates

摘要:

以2-溴-6-氟甲苯为原料，经溴化、水解、氧化及Sommlet反应合成了2-溴-6-氟溴苄、2-溴-6-氟苯甲醇、2-溴-6-氟苯甲酸和2-溴-6-氟苯甲醛，并对各工艺条件进行了优化。结构表明：以HBr/H2O2为溴化试剂，2-溴-6-氟溴苄收率为90.3%；以乙醇为溶剂，2-溴-6-氟苯甲醇收率为92.8%；以KMnO4作为氧化剂，2-溴-6-氟苯甲酸收率为58.2%；当n(2-溴-6-氟溴苄):n(六亚甲基四胺)=1:1.3时，2-溴-6-氟苯甲醛收率为79.0%。各产物结构经红外、核磁共振等技术得到了确证。

Abstract:

2-Bromo-6-fluorobenzyl bromide，2-Bromo-6-fluorophenyl methanol， 2-Bromo-6-fluorobenzoic acid and 2-Bromo-6-fluorobenzaldehyde were prepared from 2-Bromo-6-fluorotoluene by bromination，hydrolysis，oxidation and Sommlet reactions．And the synthesis process had been studied in this paper．The result showed that HBr/H2O2 as brominate agent，the yield of 2-Bromo-6-fluorobenzyl bromide was 90.3%；ethanol as solvent，the yield of 2-Bromo-6-fluorophenyl methanol was 92.8%；In the oxidation reaction，2-Bromo-6-fluorobenz- oic acid gived 58.2% with KMnO4，and under the condition of n(2-Bromo-6-fluoro benzyl bromide):n(Methenamine)=1.0:1.3，the yield of 2-Bromo-6-fluorobenzaldehyde was 79%．All products structures were characterized by nuclear magnetic resonance and infrared．