[2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉的简易合成

Concise Synthesis of [2,7,12,18-Tetramethyl-3,8-bisethyl-13,17-dicarboxy ethyl]-porphrin

摘要:

摘要：以氯化血红素(I)为原料，在甲酸-铁粉体系下，通过调节铁粉与氯化血红素的摩尔比，一步合成[2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉(双乙基次卟啉，II)。探讨了反应过程中铁粉用量、温度、时间对目标产物(II)合成的影响。结果表明，当铁粉和氯化血红素的摩尔比为15:1、反应温度为120 ℃、反应时间为2 h时，目标产物(II)产率达到97.6%。通过1H NMR、MS、UV-vis和IR测试技术对产物结构进行了表征。

Abstract:

Abstract:[2,7,12,18-Tetramethyl-3,8-bis ethyl-13,17-dicarboxy ethyl]-porphyrin (II) was directly prepared from hemin in using HCOOH-Fe powder by changing the molar ratio of Fe powder to hemin. The effects of the dostage of Fe powder, temperature, and time on the yield of II were investigated. The results show that the yield of II reaches 97.6% in the molar ratio of Fe powder to hemin 15:1 and the temperature of 120 ℃ and reaction time is 2 h. The target proucts were characterized by means of 1H NMR, MS, UV-vis and IR.