海藻酸疏水衍生物水悬纳米胶囊的制备及其性能

The Preparation and Performance of Water Suspension Nanocapsules of Alginate Hydrophobic Derivatives

摘要:

采用海藻酸辛酰胺作为囊材，基于微乳模板制备了功夫菊酯水悬纳米胶囊。采用透射电镜对纳米胶囊的形貌进行考察；结合激光粒度仪对胶囊的粒径进行分析，讨论不同海藻酸辛酰胺、氯化钙和表面活性剂的量对制备的胶囊粒径影响；并使用气相色谱测定胶囊中功夫菊酯的释放量，研究其释放性能。结果表明：随着加入表面活性剂量的增加，纳米胶囊的粒径逐渐减小；当w（功夫菊酯）=2.5%，w（表面活性剂）=17.5%，w（海藻酸辛酰胺）=1‰，w（CaCl2）=0.5‰时，水悬纳米胶囊平均粒径为7.76nm；功夫菊酯累积释放率达到60%，微乳需200min，纳米胶囊需300min，纳米胶囊减缓了芯药的释放。

Abstract:

We chose octyl-grafted alginate-amide as capsule material to prepare water suspension nanocapsule made of λ-cyhalothrin based on micro-emulsion template. The morphology of nanocapsules was characterized by transmission electron microscopy; the size of nanocapsules was characterized by laser particle size analysis and the effects of different octyl-grafted alginate-amide derivatives, calcium chloride and the amount of surfactant on the sizes of nanocapsules were discussed with the analysis of capsule particle sizes by laser particle size analyzer; moreover, the release performance of the nanocapsules was studied by the release quantity of λ-cyhalothrin determined by gas chromatography. The results indicated: the size of nanocapsules decreased with the increase of surfactant content; the average size of water suspension nanocapsules was 7.76nm when w (λ-cyhalothrin) =2.5%, w (surfactant) =17.5%, w (octyl-grafted alginate-amide derivative) = 1‰ and w (calcium chloride) = 0.5‰; in order to obtain 60% of release rate of chlorine fluorine cyanide chrysanthemum ester with high performance, the micro-emulsion needed 200min and the nanocapsule needed 300min. In all, the nanocapsules restrained the release of core drug.