共轭亚油酸钠胶束的自交联行为研究

Investigation of intramicellar self-crosslinking behaviors of sodium conjugated linoleates

摘要:

本文以高纯度天然亚油酸为原料，通过碱催化异构化反应制得一种阴离子可聚合脂质，共轭亚油酸钠。在水溶液中使共轭亚油酸钠分子自组装成球状胶束，再经自由基引发剂引发胶束内部共轭亚油酸钠分子间自交联反应，最终获得共轭亚油酸钠的球状自交联胶束。本实验探索了引发剂种类和用量、反应时间和温度等因素对共轭亚油酸钠分子自交联程度的影响，并采用TEM技术直观表征所获自交联组装体的形貌。实验结果表明，以过硫酸铵为引发剂，80 oC下使pH 13的共轭亚油酸钠水溶液交联反应10 h可以得到平均粒径为20 nm的球状自交联胶束，这是一种潜在的稳定性纳米药物载体或微反应器。

Abstract:

A kind of anionic polymerizable lipids sodium conjugated linoleates was prepared from high purity natural linoleic acid through alkali catalytic isomerization reaction. The sodium conjugated linoleates molecularly self-assembled into spherical micelles in aqueous phase, and the intramicellar self-crosslinking reaction among the sodium conjugated linoleates were induced by some free radical initiators to result in formation of spherical self-crosslinking micelles of sodium conjugated linoleates. The influence such as type and amount of initiators, reaction times and temperatures were investigated on the self-crosslinking degree of the sodium conjugated linoleates and the morphologies of the self-crosslinking assemblies were intuitively imaged by TEM. Experimental results indicated that the self-crosslinking spherical micelles of 20 nm in average diameter were obtained when self-crosslinking was induced by using ammonium persulfate as initiator at pH 13 and 80 oC for 10 h, which is a potential stable drug nanocarrier or microreactor.