用于潜在MRI造影剂的DTPA酰胺配合物的制备及性能

Synthesis and Properties of DTPA Alkyl esters complexes as potential Contrast Agent

摘要:

通过酰化反应将与水合肼缩合的靛红希夫碱引入到二乙烯三胺五乙酸（DTPA）中得到新型配体，再与GdIII、MnII、FeIII配位得到三种顺磁性金属配合物，其结构用IR, 1H NMR, ICP-AES 和元素分析进行了表征。通过测定纵向弛豫率(r1)表明，GdIII, MnII配合物的弛豫率均高于商用造影剂Gd-DTPA，此外三种配合物在牛血清蛋白(BSA)中所测得的弛豫率均高于其在水中的弛豫率。

Abstract:

Isatin Schiff bases were introduced into diethylenetriamine pentaacetic(DTPA) by acylation reaction，and their paramagnetic GdIII, MnII and FeIII coordination complexes were reported.The structures of the new compounds were established by IR, 1H NMR, ICP-AES and elemental analysis in certain cases.The in vitro studies proved that the r1 of the GdIII,MnII complexes was higher than the clinical magnetic resonance imaging contrast agent Gd-DTPA.