喷雾干燥法制备壳寡糖/水杨酸微胶囊

Microencapsulation of Salicylic Acid by Spray-drying with Chitooligosaccharide

摘要:

采用喷雾干燥法制备壳寡糖/水杨酸微胶囊，以微胶囊的含油率和包结率为指标，通过单因素考察优化后得到工艺条件为：壳寡糖浓度2%(w/w)，壳寡糖与水杨酸质量比为1.0:0.5，进风温度170癈，进风速度3.9 m?s-1，进料泵速8 RPM，得到的产品含油率和包结率分别是19.1%和21.5 %。通过用光学显微镜对微胶囊形态的观测证实水杨酸已被壳寡糖包裹，粒度分析显示得到的微胶囊平均粒径变化值在3.154μm ~ 19.751μm范围，红外光谱分析表明壳寡糖与水杨酸存在分子间相互作用，提高了水杨酸的热稳定性。

Abstract:

Chitooligosaccharide/salicylic acid microcapsules have been prepared by spray-drying method and the preparation conditions were optimized using the single factor study with oil content and encapsulation efficiency of the microcapsules as criteria. The optimal production conditions are as follows: ρ(chitooligosaccharide)= 2%(w/w), m (chitooligosaccharide):m (salicylic acid) = 1.0:0.5, inlet temperature =170癈, drying air speed= 3.9 m?s-1, rotational speed of pump feed = 8 RPM. Oil content and encapsulation efficiency of the product were 19.1% and 21.5%, respectively. The encapsulation has been confirmed by observing the morphology of microcapsules. The particle size analysis suggested that the average particle size of microcapsules was in the range of 3.154μm ~ 19.751μm. FTIR spectra were used to prove the existence of intermolecular interaction between salicylic acid and chitooligosaccharide. TG-DSC results confirmed the thermal stability of salicylic acid was improved after encapsulating by chitooligosaccharide.